品系特征：

• VISTA的胞外结构域完全被人源化；
• hVISTA的表达模式及调控是生理性的；
• 健全的鼠源免疫系统；
• mVISTA（胞外区及跨膜区）不表达，可避免交叉反应；

验证信息：

（1）hVISTA在 T 细胞上的表达情况

从WT和hVISTA小鼠上分离脾细胞，经αCD3/αCD28激活后检测；

• hVISTA小鼠上，hVISTA在CD11b+，CD4+， CD8+ 以及 Treg细胞上的表达情况与WT小鼠类似；

（2）hVISTA小鼠免疫细胞总数及分布情况

从WT和hVISTA小鼠上分离脾细胞；

• hVISTA小鼠脾细胞总细胞数以及免疫细胞分布情况与WT小鼠类似；

（3）体内药效学检测

anti-mPD-1与anti-hVISTA联合治疗效果评估

• anti-mPD-1与anti-hVISTA联合治疗效果更好。

更多详细数据请联系我们：联系我们 - 基锘威 - genOway (my3w.com)

评论

1. VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response
2. A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors
3. A VISTA on naive T cell fate
4. A new Nature report by Bristol-Myers Squibb provides new insights into VISTA biology and design of combination therapies 

已发文献

1. VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response
2. A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors
3. VISTA is an acidic pH-selective ligand for PSGL-1
4. VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 

海报

1. Anti-VISTA agents profiling: complementarity of BRGSF-HIS and hVISTA Knock-in as preclinical models for immunotherapies