品系编号：ICP3

品系编号：TNFα

品系编号：ICP55

品系编号：FCERI

品系编号：HSA/FcRn

品系编号： RHF1

品系编号：ICP2

品系编号：ICP69

品系编号：ICP11

品系编号：ICP72

品系编号：ICP13

品系编号：ICP27

品系编号：ICP47

ICP38

ICP76

ICP31

Applications of the genO‑hCCR8/hCCL1 mouse model Useful applications for researchers working on different biomedical fields, such as immuno-oncology: Assess the efficacy of CCR8 and/or CCL1-targeting therapeutics Perform tumor growth inhibition assays in the context of monotherapies or combotherapies Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential ‍

Useful applications for researchers working on different biomedical fields, such as immuno-oncology, neuroscience and inflammation: Improve the delivery of therapeutic agents aiming to cross the blood-brain barrier (BBB), via human transferrin receptor (TFCR) binding and improve their half-life Assess pharmacokinetics and pharmacodynamics (PK/PD) features, including biodistribution and binding affinity Screen compounds based on extended half-life Assess the efficacy of optimized therapeutics such as Fc-engineered antibodies, constructs fused to hSA, HhSA- and/or FcRn-binding proteins or small molecules

Useful applications for researchers working on different biomedical fields, such as immuno-oncology, infectious diseases and autoimmunity: Assess pharmacokinetics and pharmacodynamics (PK/PD) features, including biodistribution and binding affinity‍ Screen FcR-binding therapeutics based on extended half-life ‍Assess the efficacy of optimized therapeutics such as Fc-engineered antibodies, constructs fused to hSA, FcRn-binding proteins or small molecules ‍

Useful applications for researchers working in different biomedical fields, such as immuno-oncology, inflammation and autoimmunity: Assess the efficacy of CD47- and/or SIRPα-targeting therapeutics Perform tumor growth inhibition assays in the context of monotherapies or combotherapies Evaluate the safety and toxicity of compounds Analyze the biodistribution of CD47- and/or SIRPα-targeting compounds Investigate the mode of action (MoA) of CD47- and/or SIRPα-targeting compounds and understand their therapeutic potential ‍

Broad range of applications in the fields of metabolism, autoimmunity and neuroscience: Assess the efficacy of GLP-1R targeting compounds, such as in the context of treating type 2 diabetes and obesity Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential ‍