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Human GLP-1R expression pattern in brain, liver and lung recapitulates mGlp-1r

hGLP-1R and mGlp-1r expression assessed in brain, liver and lung of WT and genO-hGLP1R mice by RT-qPCR.

In vivo, DNG human-specific agonist improves glucose tolerance in genO‑hGLP-1R mice

Blood glucose was monitored every 30 minutes.

DNG efficiently decreases circulating glucose in genO‑hGLP-1R model.

Danuglipron (PF-06882961) improves glucose tolerance and plasma insulin levels in genO‑hGLP-1R mouse model

13 genO‑hGLP-1R or WT mice were injected with Danuglipron or vehicle and 15 minutes later administered 40% dextrose at 2g/kg. (A) Blood glucose was measured via tail nick using a handheld glucometer at the indicated timepoints. (B) Blood samples were collected to measure plasma insulin by ELISA at the indicated timepoints.