• Human cGAS expression in brain and lung of cGAS humanized mice

  cGAS expression was assessed in brain and lung of 9-week-old WT and hcGAS mice by Western Blot.

   

  

• Human cGAS antagonist prevents BCV-induced cytokine release in hcGAS, but not in WT mice

  hcGAS and WT mice were treated with anti-cGAS antibody or vehicule and, after 24h, were injected with different dosage of BCV. 6h later, plasma was harvested from the mice and cytokine levels (IFN-α, IP-10, IFN-β) were evaluated.

  

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