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模型资源

Physiological regulation and expression pattern of human CCR8 and human CCL1
Functional CCR8/CCL1 signaling axis
Fully functional mouse immune system
Lack of expression of the murine target genes

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Tumor-infiltrated Tregs express CCR8, contrary to peripheral Tregs

Gating on single, live, CD45+, CD3+, CD4+, FoxP3CCR8Treg cells.

Anti-hCCR8-AFUC-induced anti-tumor activity