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模型资源

首页 模型资源 靶点人源化模型 genO‑hCD47/hSIRPα model
  • Expression of different human CD47 and human SIRPα isoforms
  • Physiological regulation and expression patterns of the human CD47 and human SIRPα
  • Preservation of the target-ligand interaction
  • Fully functional mouse immune system
  • Lack of expression of the murine target genes, thus avoiding cross-reactivity
  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Magrolimab-induced transient decrease of red blood cells (RBCs) and hemoglobin corroborates clinical findings

Anti-CD47 Magrolimab-induced anti-tumor activity

hCD47 and hSIRPα expression pattern in genO‑hCD47/hSIRPα mice recapitulates mCD47 and mSIRPα in wild-type mice

Splenocytes from genO‑hCD47/hSIRPα. Expression of mCD47 and mSIRPα (upper panel), and hCD47 and hSIRPα (lower panel) were evaluated on splenic dendritic cells (DC) (viable, CD3-CD19-CD11b+CD11c+).