• EL4-hCD19-LZ cells homogeneously express human CD19 in vitro

  Expression analysis by flow cytometry. Human CD19 expression was assessed in EL4 parental cell line (left), human control cells – PBMC (center), and EL4-hCD19-LZ cell line (right).

   

  

• EL4-hCD19-LZ cells form infiltrated tumors in immunocompetent mice

  Left figure. Humanized CD3 C57/Bl6 mice were injected (s.c.) with 1x10⁶ EL4-hCD19-LZ cells. Tumor growth was measured every 2 to 4 days. Tumor size (mm³) = (width² x length)/2.

  Right figure. Medium (200 mm³) and large (800 mm³) tumors were collected and tumor composition was determined by flow cytometry.

  

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Commentaries

1. Development of a new hSIRPα-specific radiotracer for non-invasive PET imaging using genOway’s double humanized hCD47/hSIRPα mouse and MC38-hPD-L1-hCD47-LZ cell line
2. CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity
3. A new promising family of small molecules regulating the PD-L1/PD-1 signaling pathway
4. Improving in vitro models: the coming of age of organoids
5. iPS technology: Four factors that will change the world… some day

Scientific articles

1. Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells
2. CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity
3. ERα-36 regulates progesterone receptor activity in breast cancer
4. T-cells expressing a chimeric-PD1-Dap10-CD3zeta receptor reduce tumour burden in multiple murine syngeneic models of solid cancer
5. Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF
6. SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2