The CT26.WT cell line was derived and subcloned from Balb/c murine colon carcinoma and forms tumors at high frequency when inoculated subcutaneously. We generated a CT26‑hPD‑L1 clonal cell line expressing human PD‑L1.
As for our MC38-hPD-L1 cell line, the CT26-hPD-L1 cell line can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.
CT26-Pd-l1 Knockout tumor cell line:
Use our CT26-Pd-l1 Knockout clones for target validation and mechanistic studies.
We generated a CT26-hPD-L1 clonal cell line expressing high levels of human PD-L1, and forming solid tumors in vivo.
Expression analysis by flow cytometry. (A) mPd‑l1 expression in parental cell line CT26.WT and mPd‑l1 Knockout (KO) cells. (B) hPD‑L1 expression in human control cell line, CT26.WT parental cell line and CT26‑hPD‑L1 cell line. mPd‑l1 KO clone was generated, then human PD‑L1 was stably overexpressed in KO cells. Overexpressing clones were obtained through Neomycin selection.
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